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mb  For all the laurels heaped upon Henderson and the generation of epidemiologists who slew smallpox, eradicating polio may be the hardest initiative that the world public-health community has ever undertaken. Based on the timeline with smallpox, the original vaccination plan in 1988 was that polio would be gone by the turn of the millennium. But in 2000 there were still roughly 700 confirmed cases of polio paralysis worldwide, and the disease remained stubbornly entrenched in Africa and South Asia. Now, 13 years later, the target date has been pushed back to 2018. Reaching that goal depends on the vaccinators who go door to door in the world’s most unstable regions, trying to immunize nearly every child.